Table 4

Neutropenia per course by dose level

Dose levelNo. of patientsa/ coursesCTC grade of neutropaeniaMedian nadir, (× 109/liter) (range)Median time to nadir (days) (range)Febrile neutropenia
34
n/Nb%n/N%
 7 mg/m21/13.4010
14 mg/m22/23.27 (3.24–3.30)17 (17–17)
28 mg/m29/172.30 (1.2–7.80)15 (4–22)
40 mg/m221/6610/21322/231.15 (0.30–7.30)15 (3–29)2c
50 mg/m218/6311/233711/20320.70 (0.12–3.50)15 (5–29)2
60 mg/m23/33/31000.21 (0.14–0.49)13 (12–15)2
50 mg/m2 (q3 wks)8/336/9276/18550.46 (0.15–2.67)14 (7–19)1d
  • a Total number of patients treated at this dose level for at least one course.

  • b n, number of patients developing grade 3 or 4 neutropaenia; N, number of courses at that dose level in which the degree of toxicity was observed; %, percentage of courses compared to total number given where that degree neutropaenia observed.

  • c Fatal septic shock during neutropenic period in 1 patient.

  • d Neutropenic sepsis, leading to hypotension and to fatal atrial flutter in 1 patient.