Table 5

Nonhaematological toxicity any cause by course

Dosed1, d8, d15 q 4 weeklyD1, d8 q 3 weekly 50 mg/m2
40 mg/m250 mg/m260 mg/m2
No. courses given6663333
CTC gradeAny (grade 3/4)Any (grade 3/4)Any (grade 3/4)Any (grade 3/4)
Asthenia37 (3)46 (3)013 (5)
Nausea/vomiting25 (2)33 (6)1 (0)13 (2)
Diarrhea26 (3)38 (5)3 (1)13 (1)
Arthralgia/myalgia14 (1)32 (2)1 (0)5 (0)
Alopecia20 (0)34 (0)2 (0)29 (5)
Mucositis7 (0)13 (1)1 (1)0
Peripheral neuropathy26 (1)40 (1)2 (0)14 (0)