Table 3

Hypercalcemia toxicity data

Cohort (dose)Number of evaluablea patientsGrade of toxicity
1234
1 (5.0 μg/day)30000
2 (7.5 μg/day)31000
3 (10.0 μg/day)30000
4 (12.5 μg/day)30100
5 (15.0 μg/day)921b1c0
  • a Evaluable course for toxicity was ≥4 weeks of therapy.

  • b Patient developed associated reversible grade 2 increase in serum creatinine.

  • c Patient developed associated reversible grade 3 increase in serum creatinine.