Table 3

Minimum effective Irofulven dose associated with objective regressions of xenografts after i.v. administration

Dose (mg/kg)Tumor linesMGI AUC (ng/ml∗h)
1.3Rh30214
2.0Rh28, DAOY329
3.0D283, SJ-BT27, SJ-BT34a, SJ-BT36, NB1643494
4.6SJ-BT12, SJ-BT16, SJ-BT37, SJ-BT40, SJ-GBM2, NB-1382, Rh18757
7.0SJ-BT29, NB-1691, Rh361152
  • a Lowest dosage level evaluated.