Table 5

Summary of Irofulven pharmacokinetic parameter estimates after i.v. administration

Pharmacokinetic parameterNontumorSJ-BT29SJ-BT33
ke (h−1)7.5 ± 1.06.55.2
Vc (liter/m2)0.00238 ± 0.0010.003150.00377
t1/2α (min)5.4 ± 0.86.07.4
t1/2β (min)54.5 ± 12.5105.682.8
Cl (liter/h/m2)0.0166 ± 0.00420.01950.0194
Vdss (liter/m2)0.0037 ± 0.00170.00790.0057
Cmax (ng/ml)9064 ± 278878525675
AUC0→∞ (ng/ml∗h)1152 ± 5710111060