Immunohistochemistry staining index for markers of stromal cell differentiation
Marker | Normal prostate stroma (n = 84) | Gleason 3 cancer reactive stroma (n = 89) | Pa | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zero | Low | Moderate | High | Zero | Low | Moderate | High | ||||||||
Vimentin | 0 | 74 | 9 | 1 | 2 | 36 | 34 | 17 | <0.001 | ||||||
α-Actin | 0 | 0 | 4 | 80 | 1 | 25 | 30 | 33 | <0.001 | ||||||
Calponin | 0 | 2 | 26 | 56 | 14 | 55 | 14 | 6 | <0.001 |
a Fisher exact test comparing normal stroma to Gleason 3 reactive stroma (zero/low staining versus moderate/high staining).