Table 3

Occurrence of hematologic toxicity at all dose levels

Number of patients per schedule.

Weekly schedule (n = 27)Two-weekly schedule (n = 41)
LeukocytopeniaCTC 16 (22%)9 (22%)
CTC 24 (15%)3 (7%)
CTC 3a3 (11%)
NeutropeniaCTC 14 (15%)5 (12%)
CTC 23 (11%)8 (20%)
CTC 36 (22%)1 (2%)
TrombocytopeniaCTC 17 (26%)11 (27%)
CTC 22 (7%)3 (7%)
CTC 35 (19%)
AnemiaCTC 15 (19%)8 (20%)
CTC 27 (26%)14 (34%)
CTC 33 (11%)3 (7%)
  • a Hematologic toxicity never exceeded CTC grade 3.