Table 4

Occurrence of nonhematologic toxicity at all dose levels

Number of patients per schedule.

Weekly schedule (n = 27)Two-weekly schedule (n = 41)
NauseaCTC 116 (59%)21 (51%)
CTC 27 (26%)16 (39%)
CTC 31 (4%)
VomitingCTC 113 (48%)16 (39%)
CTC 23 (11%)12 (29%)
CTC 31 (4%)
ConstipationCTC 115 (56%)11 (41%)
CTC 24 (15%)4 (10%)
CTC 3
FatigueCTC 14 (15%)7 (17%)
CTC 27 (26%)6 (15%)
CTC 32 (7%)1 (2%)
NeuropathyCTC 17 (26%)8 (20%)
CTC 21 (2%)
CTC 3
AlopeciaCTC 18 (30%)11 (41%)
CTC 21 (4%)1 (2%)
OtotoxicityCTC 14 (15%)10 (24%)
CTC 22 (7%)5 (12%)
CTC 31 (4%)1 (2%)