Table 1

Dose escalation schedule

Part A
CohortDose (mg/m2)No. of days/weekNo. of consecutive weeksObservation period (wk)No. of patients
Solid tumor patients
 1a753121
 2a1503121
 3a3003121
 4a6003121
 5a9003124
Part B
CohortDose (mg/m2)No. of days/weekNo. of consecutive weeksObservation period (wk)No. of patients
Solid tumor patients
 1b3005121
 2b3005223
 3b3005313
 4b6005313
 5b9005317
CohortDose (mg/m2)No. of days/weekNo. of consecutive weeksObservation period (wk)No. of patients
Hematological patients
 3b3005317
 4b6005315