Table 3

Common adverse events

a. Solid tumors
Adverse eventGrade
1+2+3+4+5+
Cardiac/thromboembolic
 ARDSa0 (0%)0 (0%)0 (0%)1 (4%)0 (0%)
 Cardiac ischemia0 (0%)1 (4%)0 (0%)0 (0%)1 (4%)
 Hypotension0 (0%)1 (4%)1 (4%)0 (0%)0 (0%)
 Thrombosis0 (0%)0 (0%)0 (0%)1 (4%)0 (0%)
Hematological
 Hemoglobin7 (28%)14 (56%)2 (8%)0 (0%)0 (0%)
 Leukocytes8 (32%)0 (0%)0 (0%)0 (0%)0 (0%)
 Platelets11 (44%)3 (12%)1 (4%)0 (0%)0 (0%)
Metabolic
 Creatinine4 (16%)4 (16%)0 (0%)0 (0%)0 (0%)
 Hyperglycemia13 (52%)6 (24%)4 (16%)0 (0%)0 (0%)
 AST8 (32%)1 (4%)0 (0%)0 (0%)0 (0%)
 ALT5 (24%)2 (8%)0 (0%)0 (0%)0 (0%)
Gastrointestinal
 Anorexia13 (52%)2 (8%)0 (0%)0 (0%)0 (0%)
 Constipation10 (40%)4 (16%)0 (0%)1 (4%)0 (0%)
 Diarrhea15 (60%)1 (4%)1 (4%)0 (0%)0 (0%)
 Vomiting6 (24%)4 (16%)0 (0%)0 (0%)0 (0%)
General
 Abdominal pain/cramping3 (12%)1 (4%)1 (4%)1 (4%)0 (0%)
 Dyspnea5 (20%)6 (24%)1 (4%)0 (0%)0 (0%)
 Fatigue13 (52%)1 (4%)1 (4%)0 (0%)0 (0%)
 Tumor pain0 (0%)0 (0%)2 (8%)0 (0%)0 (0%)
b. Hematological malignancies
Adverse eventGrade
1+2+3+4+
Cardiac/thromboembolic
 Hypotension1 (8%)2 (17%)0 (0%)0 (0%)
 Pulmonary, other0 (0%)0 (0%)1 (8%)0 (0%)
 Thrombosis0 (0%)1 (8%)2 (17%)0 (0%)
Hematological
 Hemoglobin2 (8%)5 (42%)5 (42%)0 (0%)
 Leukocytes1 (8%)1 (8%)0 (0%)2 (17%)
 Platelets4 (33%)2 (17%)2 (17%)0 (0%)
Metabolic
 Creatinine2 (17%)1 (8%)0 (0%)0 (0%)
 Hyperglycemia8 (67%)2 (17%)0 (0%)0 (0%)
 AST alanine3 (25%)0 (0%)0 (0%)0 (0%)
 Aminotransferase3 (25%)0 (0%)0 (0%)0 (0%)
Gastrointestinal
 Anorexia6 (50%)1 (8%)0 (0%)0 (0%)
 Constipation4 (33%)0 (0%)1 (8%)0 (0%)
 Diarrhea4 (33%)0 (0%)1 (8%)0 (0%)
 Vomiting1 (8%)2 (17%)0 (0%)0 (0%)
General
 Abdominal pain/cramping1 (8%)1 (8%)0 (0%)0 (0%)
 Dyspnea3 (25%)2 (17%)3 (25%)1 (8%)
 Fatigue3 (25%)4 (33%)3 (25%)0 (0%)
 Tumor pain1 (8%)0 (0%)0 (0%)0 (0%)
  • a Acute respiratory distress syndrome.