Table 2

Dose escalation scheme and incidence of DLT

Dose (mg/m2)NewEscalated to this doseReduced to this doseTotal no. patientsTotal no. cyclesNew patients with DLTa/total no. of new patients
200100140/1
4002103100/2
6606006181/6
88060410271/6
11009009191/9
Total24783/24
  • a First course only.