Table 3

Hematological toxicity of DHA-paclitaxel (NCI-CTC, version 2.0)

Dose (mg/m2)No. of patients/No. of cyclesNeutrophil nadirTotal no. of patients with neutropenia (total no. of cycles)Platelet nadirNo. of patients with thrombocytopenia
Median ANC (range)/mm3Median day (range)Grade 3Grade 4Grade 4 > 5 daysGrade 4 + feverMedian (range) × 103/mm3Median dayGrade 3Grade 4
2001/434791500002811500
(3357–4583)(10–18)(277–283)
4003/102095150000232800
(1120–2724)(8–23)(119–301)
6606/18838153 (4)2 (6)10206800
(161–2999)(8–15)(65–334)
88010/2769811.53 (4)6 (10)02 (2)184800
(0–4800)(8–15)(111–383)
11009/19403124 (4)5 (10)02 (2)178800
(23–2850)(8–15)(78–292)