Table 6

Paclitaxel pharmacokinetic parametersa

Dose (mg/m2)No. of patientstfbt1/2 (h)Cmax (ng/ml)AUC (ng/ml × h)Paclitaxel: DHA-paclitaxel AUC ratio (%)
(24 h)(tf)(inf)
20016.0NC42NA112NC0.013
40018.4NC76NA183NC0.011
6606275211890690629030.023
(23–29)(52)(70)(25)(25)(42)(20)
880234, NC26, 26110, 1341128, 14041128, 14042762, NC0.025, 0.035
880354501711639277957650.027
(26–74)(51)(37)(39)(58)(62)(31)
11009157852822702876410,7050.058
(71–314)(101)(46)(53)(55)(60)(80)
  • a Values represent mean (CV%).

  • b tf, time of the final quantifiable sample; NC, not calculated; NA, not applicable; t1/2, apparent half-life; Cmax, maximum plasma concentration; AUC (24 h), area under the concentration-time curve from time 0 to 24 h; AUC (tf), AUC from time 0 to tf; AUC (inf), AUC from time 0 to infinity.