Table 3

Distribution of immunohistochemical characteristics in familial IDCs

BRCA1 n (%)PBRCA(−) n (%)PBRCA2 n (%)
ER
 Negative14 (73.7)7 (25.0)1 (7.1)
 Positive5 (26.3)0.00121 (75.0)NS13 (92.9)
PR
 Negative15 (75)9 (32.1)3 (21.4)
 Positive4 (21.1)0.00219 (67.9)NS11 (78.6)
BCL2
 Negative17 (89.5)12 (44)8 (57.1)
 Positive2 (10.5)0.00515 (55.6)NS6 (42.9)
Ki-67
 0–5%5 (26.3)25 (92.6)8 (57.1)
 6–25%8 (42.1)2 (7.4)5 (35.7)
 >25%6 (31.6)<0.000100.0211 (7.1)
P53
 Negative9 (47.4)26 (96.3)11 (84.6)
 Positive10 (52.6)0.0001 (3.7)NS2 (15.4)
HER-2 (IHC)
 Negative (0/+)19 (100)26 (96.3)9 (64.3)
 Positive (++)005 (35.7)
 Positive (+++)0NS1 (3.7)0.0040
E-CD
 Preserved9 (47.4)12 (42.9)12 (80.0)
 Reduced10 (52.6)NS16 (57.1)0.0193 (20.0)
P-CD
 Absent15 (78.9)29 (100)14 (93.3)
 Present4 (21.1)0.0100NS1 (6.7)
β-catenin
 Preserved6 (31.6)6 (21.4)7 (46.7)
 Reduced13 (68.4)NS22 (78.6)NS8 (53.3)
γ-catenin
 Preserved5 (27.8)6 (21.4)7 (46.7)
 Reduced13 (72.2)NS22 (78.6)NS8 (53.3)
p120ctn
 Preserved4 (22.2)7 (25.9)5 (38.5)
 Reduced14 (77.8)NS20 (74.1)NS8 (61.5)