Table 1

In vitro interaction effects for combination treatments

Cell lineTRA-8 + AdriamycinTRA-8 + Paclitaxel
InteractionPaInteractionPa
LCC6Synergistic<0.001Additive0.624
MDA-MB-453Synergistic<0.001No responseb0.615
2LMPAdditive0.153Additive0.937
MDA-MB-231Additive0.663Additive0.064
BT-474Synergistic<0.001NDc0.992
ZR-75-1Synergistic0.013Additive0.172
DY36T2NDc0.808NDc0.798
MDA-MB-468Additive0.184Additive0.724
SK-BR-3Additive0.361No responseb0.871
  • a P refers to the significance of the synergistic interaction term. If both TRA-8 and drug effects were significant and the interaction term was significant, then the combination effects were considered synergistic. If the interaction P is not <0.05, then the combination effects were considered additive.

  • b There was no significant dose response for either agent.

  • c Not determined because the TRA-8 effect was not significant, but the Adriamycin/paclitaxel effect was significant.