Table 3

Microsatellite instability in human pancreatic xenografts before and after treatment with BCNU alone and with BCNU after inactivation of MGMT with BG or dBG

Cell linesD2S123 2D2S136 (2p13-p14)D3S1067 (3p14.3-p14)D5S 107 (5q11.2-q13.3)D6S87 (6q)D18 S34 (18q12.2-q22.3)
PANC-1/control
BCNU
dBG/BCNU
BG/BCNU
CFPAC-1/control
BCNU
dBG/BCNU+
BG/BCNU
MIA PaCa-2/control
BCNU+
dBG/BCNU
BG/BCNU+
BxPC-3/control
BCNU+++++
dBG/BCNU
BG/BCNU
CAPAN-2/control
BCNU
BG/BCNU