Table 1

Biodistribution data of mice carrying s.c. SK-RC-52 xenografts injected with different doses of bispecific antibodya

0.1 nmol0.2 nmol0.5 nmol1.0 nmol
Blood6.75 ± 0.6210.99 ± 0.9515.56 ± 2.6415.49 ± 1.83
Muscle0.64 ± 0.100.90 ± 0.170.84 ± 0.151.00 ± 0.31
Tumor26.34 ± 9.5136.97 ± 19.3513.63 ± 8.199.33 ± 1.53
Lung3.85 ± 0.895.75 ± 0.548.51 ± 1.448.55 ± 1.09
Spleen2.29 ± 1.183.46 ± 0.985.29 ± 2.646.68 ± 3.77
Kidney3.75 ± 0.274.50 ± 0.235.17 ± 0.615.25 ± 0.70
Liver4.62 ± 1.187.90 ± 2.2011.71 ± 2.3610.96 ± 2.89
Intestine1.87 ± 0.392.48 ± 0.413.62 ± 0.715.32 ± 2.69
T/B3.96 ± 1.563.49 ± 2.220.86 ± 0.490.60 ± 0.04
  • a Tumor-bearing mice were pretargeted with various doses of bsMAb G250xDTIn1 followed by administration, 24 h later, of 3.8 pmol of 99mTc-labeled TscGC-diDTPA(In)-KYKK (5 mice/group). Mice were killed 6 h p.i. of the radiolabel. Uptake is expressed as %ID/g.