Table 2

Biodistribution data of mice carrying s.c. SK-RC-52 xenografts pretargeted with 0.1 nmol of bsMAb, injected with different doses of peptidea

0.3 pmol1.2 pmol3.8 pmol12.6 pmol
Blood4.28 ± 0.594.92 ± 1.495.18 ± 0.785.02 ± 1.01
Muscle0.38 ± 0.080.38 ± 0.120.41 ± 0.060.49 ± 0.09
Tumor27.84 ± 7.7323.53 ± 5.2932.57 ± 6.0818.22 ± 3.38
Lung2.27 ± 0.252.45 ± 0.532.97 ± 0.622.92 ± 0.47
Spleen1.59 ± 1.241.68 ± 0.391.76 ± 0.611.85 ± 1.72
Kidney3.58 ± 0.193.70 ± 0.383.76 ± 0.383.74 ± 0.37
Liver6.49 ± 2.068.52 ± 2.935.43 ± 1.764.75 ± 1.74
Intestine0.95 ± 0.181.14 ± 0.321.24 ± 0.341.41 ± 0.45
T/B6.66 ± 2.425.23 ± 2.156.35 ± 1.183.80 ± 1.18
  • a Tumor-bearing mice were pretargeted with 0.1 nmol of bsMAb G250xDTIn1 followed by administration, 24 h later, of various doses of 99mTc-labeled TscGC-diDTPA(In)-KYKK (5 mice/group). Mice were killed 6 h p.i. of the radiolabel. Uptake is expressed as %ID/g.