Table 2

ORs and 95% CIs for the association between ovarian cancer risk and BRCA1 and BRCA2 polymorphisms

GenotypeCases n (%)Controls n (%)Adjusted ORa95% CI
BRCA2 N372H
 NN169 (54)227 (57)1.0(Referent)
 NH128 (41)146 (37)1.2(0.8–1.6)
 HH15 (5)25 (6)0.8(0.4–1.5)
 NH/HH143 (46)171 (43)1.1(0.8–1.5)
BRCA1 P871L
 PP127 (42)141 (36)1.0(Referent)
 PL123 (40)174 (45)0.8(0.6–1.1)
 LL55 (18)73 (19)0.9(0.6–1.5)
 PL/LL178 (58)247 (64)0.8(0.6–1.1)
BRCA1 Q356R
 QQ275 (91)344 (90)1.0(Referent)
 QR27 (9)39 (10)0.9(0.5–1.4)
 RR1 (0)1 (0)1.3(0.1–20.2)
 QR/RR28 (9)40 (10)0.9(0.5–1.4)
  • a Adjusted for race and age.