Table 3

ORs and 95% CIs for the association of serous ovarian cancer risk and BRCA1 and BRCA2 polymorphisms

GenotypeCases n %Controls n %Adjusted ORa95% CI
BRCA2 N372H
 NN100 (54)227 (57)1.0(Referent)
 NH76 (41)146 (37)1.2(0.8–1.7)
 HH9 (5)25 (6)0.8(0.4–1.8)
 NH/HH85 (46)171 (43)1.1(0.8–1.6)
BRCA1 P871L
 PP60 (39)141 (36)1.0(Referent)
 PL64 (42)174 (45)0.9(0.6–1.3)
 LL30 (19)73 (19)1.0(0.6–1.7)
 PL/LL94 (61)247 (64)0.9(0.6–1.3)
BRCA1 Q356R
 QQ167 (92)344 (90)1.0(Referent)
 QR14 (8)39 (10)0.7(0.4–1.4)
 RR0 (0)1 (0)Inestimable
 QR/RR14 (8)40 (10)0.7(0.4–1.4)
  • a Adjusted for race and age.