Table 2

The effect of treatment with cytotoxic LH-RH analogue AN-152 and DOX on histologic characteristics of s.c. implanted MDA-PCa-2b tumors (experiment II) and of intraosseously implanted C4-2 tumors (experiment III) in nude mice and on the weights of reproductive organs

Treatment groupsHistologic characteristics of tumorsWeights of the reproductive organs
Mitotic indexApoptotic indexRatio of apoptotic to mitotic indicesNo. of AgNORs per cellTesticles (mg)Seminal vesicles (mg)Prostate (mg)
Experiment II (s.c. MDA-PCa-2b tumors)
 1. Control7.2 ± 0.83.7 ± 0.50.55 ± 0.077.0 ± 0.1180.0 ± 11.0108.1 ± 15.865.0 ± 5.3
 2. Decapeptyl4.7 ± 0.43.7 ± 0.50.86 ± 0.176.3 ± 0.2a141.4 ± 7.0b64.3 ± 6.5a50.0 ± 2.1a
 3. DOX5.9 ± 1.12.8 ± 0.40.60 ± 0.196.4 ± 0.271.4 ± 5.9b80.0 ± 18.146.6 ± 8.9
 4. AN-1526.1 ± 0.32.1 ± 0.20.35 ± 0.056.3 ± 0.2a84.0 ± 5.0b86.0 ± 8.748.0 ± 3.7
Experiment III (intraosseous C4-2 tumors)
 1. Control22.6 ± 6.02.7 ± 0.90.19 ± 0.118.1 ± 0.1200.0 ± 12.4155.0 ± 31.2111.8 ± 3.7
 2. DOX18.7 ± 3.52.6 ± 0.50.19 ± 0.067.5 ± 0.288.0 ± 11.1b130.2 ± 7.498.0 ± 19.3
 3. AN-1526.4 ± 2.36.8 ± 0.9b1.91 ± 0.70b6.5 ± 0.2a57.5 ± 2.5b160.0 ± 15.397.5 ± 13.1
  • a P < 0.05 vs. control.

  • b P < 0.01 vs. control.