Table 2

Expression of IL-15 and TGF-α in 70 clinical specimens of human colorectal cancers is associated with induction of hyperplasia in mucosa adjacent to the lesions

Mucosal hyperplasiaaNo. of casesNo. of positive casesb
IL-15TGF-αBoth
Positive44101123
Negative26183
P c 0.04441.00000.0007
  • a Hyperplastic change of mucosa was defined morphologically as cryptic columns 1.5 times taller than control mucosa 10 cm from cancer lesion.

  • b Positivity was determined by immunostaining.

  • c Calculated using the two-tailed Fisher’s exact test.