Table 5

Signal transduction pathway genes

Hormone sensitiveHormone escapedP
MAPK pathway
FGR(Src-2)(control MYCL2)0% (0/19)37% (7/19)0.016
HRAS (control FGF3)5% (1/19)16% (3/19)0.500
RAF1 (control TERC)5% (1/19)17% (3/18)0.500
MYC/MYCL1 (control MOSF/FGR)21% (4/19)63% (12/19)0.027
FGR/HRAS/RAF110% (2/19)60% (11/19)0.005
FGR/HRAS/RAF1MYC/MYCL1 31% (6/19)74% (14/19)0.024
P13K pathway
FGR(Src-2) (control MYCL2)0% (0/19)37% (7/19)0.016
PI3K (control TERC)39% (7/18)50% (9/18)0.375
FGR(Src-2) and PI3K0% (0/19)26% (5/19)0.046
Akt (no control)0% (0/19)0% (0/19)1.000
MYB/MYB12 (control ERS/CSE1L)26% (5/19)53% (10/19)0.180
FGR(Src-2) and PI3K/MYB/MYB1226% (5/19)53% (10/19)0.180